تم الحل ✓
categoryهندسة كيميائية
schoolبكالوريوس
event_available2026-07-13
السؤال
Transcribed Image Text:
Cyclosporin A is produced by fermentation using either Cylindrocarpon lucidum Booth
or Tolypocladium inflatum Gams. The fermentation is carried out in batch reactors, which
are filled with a feed medium, inoculated with the fungi, and aerated for a period of 13
days. The reactor product is milled and extracted with 90% methanol. The methanol is
evaporated off to give an aqueous solution that is then extracted with ethylene chloride.
The organic solution is evaporated to dryness and then the product is purified by
chromatography in methanol over aluminium oxide or silica gel. Sketch a block flow
diagram of the process.
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