1. Determine renal clearance, Cl,, over the 2-4 hour time period from the data in Table 1. To do this you need to estimate AUC2-4 using the trapezoidal rule. (5 pts) AE CLT=Auch where AE the amount eliminated between ta and th. Table 1: Data obtained following a 200 mg intravenous bolus dose of a drug. Time (hr) Plasma Conc Urine Conc Urine Vol (mg/L) (ml) (mg/L) 1 7.9 280 60 2 6.3 178 72 4 4 167 110 6 2.5 114 105 8 1.6 38.9 18.5 10 1 70.6 68 12 0.63 25 120 18 0.16 11.9 311 24 0.04 4.9 204 36 ND 0.39 720 48 ND ND 687